Not available outside of the UK & Ireland.

Application

N-Nitrosodiethylamine (NDEA) has been used as a hepatocarcinogen/DNA damaging agent. It has been used as a calibration standard for gas–liquid chromatography.

Biochem/physiol Actions

N-Nitrosodiethylamine (NDEA) is a potent hepatocarcinogenic dialkylnitrosoamine. It is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. NDEA is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. It results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

Caution

Injecting any compatible solvent permits preparation of any desired strength solution without exposure.

Legal Information

Isopac is a registered trademark of Sigma-Aldrich Co. LLC

Packaging

1 g in serum bottle

Packaged in a 100 mL serum bottle with silicon/PTFE septum and aluminum tear seal.

Reconstitution

Dissolving the contents in 100 mL of solvent yields a 1% solution.