Not available outside of the UK & Ireland.

Application

4,6-Dioxoheptanoic acid has been used: as component of dendritic cell conditioning medium and in the inhibition of ALA dehydratase (ALAD) in dendritic cells(50) as an inhibitor of heme biosynthesis in human mononuclear cells(51) and HeLa cells(52) as a standard for the quantification of succinylacetone from Plasmodium falciparum cultures(53)

Biochem/physiol Actions

An inhibitor of heme biosynthesis

4,6-Dioxoheptanoic acid is an inhibitor of heme biosynthesis. It is a catabolic byproduct of tyrosine breakdown and inhibits δ-aminolevulinic acid (ALA) dehydratase enzyme. It is a potential marker for detecting tyrosinemia type I and is measured in dried blood spot of new borns.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. D1415.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Packaging

1 g in glass bottle

100, 500 mg in glass bottle