Not available outside of the UK & Ireland.

Application

Cyclophosphamide, a nitrogen mustard DNA alkylating agent, is used to study its mechanisms of action as an anticancer and antiimmunity drug.

Biochem/physiol Actions

Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.

Caution

Injecting a compatible solvent directly into the vial permits preparation of any desired strength solution without exposure.

Legal Information

Isopac is a registered trademark of Sigma-Aldrich Co. LLC

Packaging

1 g in serum bottle

Packaged in a 100 mL serum bottle with silicon/PTFE septum and aluminum tear seal.

Reconstitution

Dissolving the contents in 100 mL of solvent yields a 1% solution.