Not available outside of the UK & Ireland.

Analysis Note

Molecular weight by MALLS.

Application

Poly-L-histidine has been used:as a polycation for the dispersion of multi-wall carbon nanotubes (MWCNTs)as a polyionic compound to investigate its ability to rupture extracellular enveloped virus membranein screening its anti-prion activity in cell based and in vivo anti-prion assay

Biochem/physiol Actions

Poly-L-histidine (Phis) copolymers are biocompatible, pH responsive and are less toxic. It exhibits endolysosomal escape funcationality. The copolymer of Phis with poly(ethylene glycol)−poly(d,l-lactide) (PEG-PLA) is effective in delivering doxorubicin. pH sensitive poly(l-histidine) copolymer micelles have application in delivering anticancer drugs in acidic microenvironment.

General description

Poly-L-histidine is an amphoteric compound. The imidazole ring in its structure enables protonation−deprotonation.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Packaging

10, 50, 100 mg in poly bottle