Nonactin, from Streptomyces griseus, >=98% (function tested, HPLC)

Code: n2286-10mg D2-231

Not available outside of the UK & Ireland.

Application

Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. Nonactin has been reported to inhibit the processing of cytop...


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$203.00 10MG
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Not available outside of the UK & Ireland.

Application

Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is an uncoupler of oxidative phosphorylation .

Biochem/physiol Actions

Nonactin is used as a neutral lipid membrane soluble ammonium (and potassium) ionophore, and to inhibit surface expression of certain heat shock proteins (HSP60) .

General description

Chemical structure: macrolide

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Packaging

10, 100 mg in glass bottle

antibiotic activity spectrumGram-positive bacteria
assay≥98.0% (Total homologs, HPLC)
biological sourceStreptomyces griseus
descriptionNatural macrotetrolide, may contain homologues (like monactin and dinactin)
formpowder
InChI keyRMIXHJPMNBXMBU-QIIXEHPYSA-N
InChI1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-8H3/t21-,22+,23+,24-,25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-
mode of actionDNA synthesis | interferes, cell membrane | interferes
Quality Level300
SMILES stringC[C@H]1C[C@@H]2CC[C@@H](O2)[C@@H](C)C(=O)O[C@H](C)C[C@H]3CC[C@H](O3)[C@H](C)C(=O)O[C@@H](C)C[C@@H]4CC[C@@H](O4)[C@@H](C)C(=O)O[C@H](C)C[C@H]5CC[C@H](O5)[C@H](C)C(=O)O1
solubilitychloroform: soluble 10 mg/mL
storage temp.2-8°C
Code
Description
Unit Size
List Price
Qty
N2286-100MG
Nonactin, from Streptomyces griseus, >=98% (function tested, HPLC)

Unit:100MG
List Price: $1,191.90
Source:List Price
ADD
Cas Number6833-84-7
This product has met the following criteria: