Not available outside of the UK & Ireland.

Application

Choline chloride has been used:in choline release assayas an endogenous agonist of sigma-1 receptors (Sig-1Rs)as a standard to analyse interrelationships between methionine and choline metabolism

Biochem/physiol Actions

The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes .

Choline is an essential nutrient, commonly grouped with the B complex vitamins, that plays key roles in many biological processes.

General description

Choline is a constituent of sphingomyelin and lecithin. It is a precursor of acetylcholine. Choline plays a vital role in methyl group metabolism, carcinogenesis and lipid transport. Choline deficiency is associated with fatty liver. It maintains cell structural integrity and cell signalling. Choline is implicated in the synthesis of phospholipids. It acts as a potent biomarker for ischemic heart disease.

Packaging

5, 25, 100 g in glass bottle

10 mg in autosample vial

Substrates

Choline acetyltransferase substrate