Not available outside of the UK & Ireland.

Application

Cafestol acetate has been used to determine the effects of coffee on heat shock response (HSR).

Biochem/physiol Actions

Cafestol is a coffee-specific diterpene. It has anti-carcinogenic and anti-inflammatoryactivities. Cafestol stimulates apoptosis in cells associated with colorectal and renal cancer (Caki cells). It is used to study mechanisms of anti-oxidation related to hydrogen peroxide induced oxidative stress and DNA damage. Cafestol increases the level of glutathione (GSH), by stimulating γ-glutamylcysteine synthetase. It acts as a chemopreventive agent by inducing cytochrome P-450.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C1305.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Furan-containing diterpene from green coffee beans.

Packaging

100 mg in poly bottle