Not available outside of the UK & Ireland.

General description

Adipic acid dihydrazide is a homobifunctional cross-linking reagent that is specific for aldehydes. This results in relatively stable hydrazone linkages. Adipic acid dihydrazide is generally used in the linking of glycoproteins, like antibodies, in a site-specific fashion following periodate oxidation. Oxidation and coupling may be performed at pH 5.0 due to the low pKa of the hydrazide which avoids competition by primary amines.

Other Notes

Note that the hydrazone bond may be stabilized by selective reduction using, for example, sodium cyanoborohydride.

Packaging

25, 100 g in poly bottle