Nicotinamide, >=99.5% (HPLC)

Code: 72340-1kg D2-231

Not available outside of the UK & Ireland.

Application

Nicotinamide has been used:to study its effect on the expression of sirtuin 1in nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phopshate (NAD...


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£224.00 1KG
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Not available outside of the UK & Ireland.

Application

Nicotinamide has been used:to study its effect on the expression of sirtuin 1in nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phopshate (NAD+/NADH) cycling assayin cell lysis buffer, to serve as a sirtuin 1 inhibitor in order to study its role in resveratrol (RSV)-stimulated hepatitis B virus replication

Biochem/physiol Actions

The coenzymes NAD and NADP take part in energy yielding metabolism and mediate several oxidation-reduction reactions. NAD hydrolyses to form nicotinamide, which is then transported to other tissues. Hydrolysis of nicotinamide yields nicotinic acid through salvage pathway.

Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

Nicotinamide (Niacinamide) (Nam) is a building block (active component) of coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phopshate (NADP). Nicotinamide may be used as a substrate of nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12), the rate-limiting enzyme for NAD(+) biosynthesis and an important signaling molecule.

Other Notes

Coenzymes and Cofactors, vol. 2: Pyridine Nucleotide Coenzymes

anion tracessulfate (SO42-): ≤150 mg/kg, chloride (Cl-): ≤50 mg/kg
application(s)cell analysis
assay≥99.5% (HPLC)
biological sourcesynthetic
cation tracesNa: ≤50 mg/kg, K: ≤50 mg/kg, Cr: ≤5 mg/kg, Mn: ≤5 mg/kg, Mg: ≤5 mg/kg, Ca: ≤10 mg/kg, Pb: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, Zn: ≤5 mg/kg, Ni: ≤5 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg
colorcolorless to white
formpowder or crystals
Gene Informationhuman ... PARP1(142), SIRT2(22933)
ign. residue≤0.2%
InChI keyDFPAKSUCGFBDDF-UHFFFAOYSA-N
InChI1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
loss≤0.2% loss on drying, 20 °C (HV)
mp128-131 °C, 128-131 °C (lit.)
Quality Level200
SMILES stringNC(=O)c1cccnc1
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Description
Unit Size
List Price
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72340-100G
Nicotinamide, >=99.5% (HPLC)

Unit:100G
List Price: £37.00
Source:List Price
ADD
72340-250G
Nicotinamide, >=99.5% (HPLC)

Unit:250G
List Price: £85.00
Source:List Price
ADD
Cas Number98-92-0
This product has met the following criteria: