Probenecid,

Code: p8761-100g D2-231

Not available outside of the UK & Ireland.

Application

Useful as an inhibitor of the organic anion transporter, MRP.

Probenecid has been used:as a component of phenol red free Hank′s buffer for Intracellular Ca<...


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Your Price
£407.00 100G

Not available outside of the UK & Ireland.

Application

Useful as an inhibitor of the organic anion transporter, MRP.

Probenecid has been used:as a component of phenol red free Hank′s buffer for Intracellular Ca2+-mobilization assayas a component of calcium sensitive dye for calcium mobilization Studiesas a supplement in Hank′s balanced salt solution (HBSS) assay buffer

Biochem/physiol Actions

Probenecid is a uricosuric agent, which increases uric acid removal in the urine and reduces urate reuptake. It also reduces the renal tubular excretion of many other drugs and increases their plasma concentration. The inhibitory action of probenecid is mediated by organic anion transporters. It is found useful for the treatment of gout. Probenecid is responsible for the rise in the levels of neurochemicals in the brain by preventing its movement from choroid plexus and parenchyma cells into plasma.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. P8761.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

assay≥98% (NaOH, titration)
Gene Informationhuman ... SLC22A11(55867), SLC22A6(9356), SLC22A8(9376)
InChI keyDBABZHXKTCFAPX-UHFFFAOYSA-N
InChI1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)
originatorMerck & Co., Inc., Kenilworth, NJ, U.S.
Quality Level200
SMILES stringCCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O
Code
Description
Unit Size
List Price
Qty
P8761-25G
Unit:25G
List Price: £121.00
Source:List Price
ADD
Cas Number57-66-9
This product has met the following criteria: