Not available outside of the UK & Ireland.

Application

Celastrol has been:used intraperitoneally to inject into experimental mice to study its role in nonalcoholic fatty liver disease (NAFLD)used in culture medium to study its effect on lipopolysaccharide-induced inflammatory injury in human keratinocyte cell cultureused to study its effect in vitro and in vivo in VCaP cells

Biochem/physiol Actions

Celastrol is a quinone methide triterpene naturally present in Tripterygium wilfordii. It is useful in treating rheumatoid arthritis. Celastrol prevents the action of proteasome and nuclear factor Κb.

Celastrol is a potent antioxidant, and anti-inflammatory agent. It is a novel HSP90 inhibitor (disrupts Hsp90/Cdc37 complex), that exhibits anticancer (anti-angiogenic - suppresses VEGFR expression); antioxidant (inhibits lipid peroxidation) and anti-inflammatory activity (suppresses iNOS and inflammatory cytokine production).

Packaging

10, 50 mg in glass bottle