Butenafine hydrochloride, >=98% (HPLC)

Code: b5188-50mg D2-231

Not available outside of the UK & Ireland.

Application

Butenafine hydrochloride has been used as a standard in high-performance liquid chromatography (HPLC) method to determine butenafine hydrochloride in butenafine-l...


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Your Price
£288.00 50MG

Not available outside of the UK & Ireland.

Application

Butenafine hydrochloride has been used as a standard in high-performance liquid chromatography (HPLC) method to determine butenafine hydrochloride in butenafine-loaded nanosponges.

Biochem/physiol Actions

Butenafine possesses antifungal property. It is a squalene epoxidase inhibitor. Butenafine can inhibit the synthesis of ergosterol needed in fungal cell membranes.

Butenafine exhibits fungicidal and antimycotic activity. This fungal squalene epoxidase inhibitor serves as an effective fungicide against T. rubrum, T. mentagrophytes, Microsporum canis, Aspergillus fumigatus, Sporothrix schenckii, Candida parapsilosis, and C. albicans. It is considered more effective and rapid than other antifungal drugs at curing dermatophytosis and preventing recurrences. In humans, it is used topically to treat tinea conditions and superficial candidiasis. Butenafine is considered a promising antimycotic compound to treat tinea pedis due to its efficiency, safety profile, relapse rates, and cost-effectiveness.

Features and Benefits

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Butenafine hydrochloride is chemically known as N-4-tertbutylbenzyl-N-methyl-1-naphthalenemethylamine hydrochloride. Butenafine, a benzylamine derivative, is a new generation antimycotic compound. It is easily soluble in methanol, ethanol, dichloromethane, and chloroform, but not in water. The allyl radical in butenafine hydrochloride is substituted by a butylbenzyl group.

Packaging

10, 50 mg in glass bottle

assay≥98% (HPLC)
colorwhite to off-white
formpowder
InChI keyLJBSAUIFGPSHCN-UHFFFAOYSA-N
InChI1S/C23H27N.ClH/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20;/h5-15H,16-17H2,1-4H3;1H
originatorSchering Plough
Quality Level100
SMILES stringCl.CN(Cc1ccc(cc1)C(C)(C)C)Cc2cccc3ccccc23
solubilityDMSO: ≥10 mg/mL
storage temp.room temp
Code
Description
Unit Size
List Price
Qty
B5188-10MG
Unit:10MG
List Price: £76.10
Source:List Price
ADD
Cas Number101827-46-7
This product has met the following criteria: