(E/Z)-BCI hydrochloride, >=98% (HPLC)

Code: b4313-25mg D2-231

Not available outside of the UK & Ireland.

Application

(E/Z)-BCI hydrochloride has been used:to evaluate the role of the Duox-H2O2-Dusp6 derepression signaling pathway in heart regenerationas an ...


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Your Price
£801.00 25MG
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Not available outside of the UK & Ireland.

Application

(E/Z)-BCI hydrochloride has been used:to evaluate the role of the Duox-H2O2-Dusp6 derepression signaling pathway in heart regenerationas an MKP-1 inhibitor to investigate the role of MKP-1 on bexarotent-induced effectsas a dual specificity phosphatase 6 (DUSP6) inhibitor to study its effects on the proliferation of SKOV3 cells

Biochem/physiol Actions

BCI is an allosteric inhibitor of Dusp6 that acts within the phosphatase domain to prevent the catalytic stimulation of phosphatase activity induced by ERK2 substrate binding. BCI also hyperactivates FGF signaling, since Dusp6 functions as a feedback regulator of FGF signaling.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyJPATUDRDKCLPTI-UHFFFAOYSA-N
InChI1S/C22H23NO.ClH/c24-22-19-14-8-7-13-18(19)21(23-17-11-5-2-6-12-17)20(22)15-16-9-3-1-4-10-16;/h1,3-4,7-10,13-15,17,21,23H,2,5-6,11-12H2;1H
Quality Level100
SMILES stringCl.O=C1C(=Cc2ccccc2)C(NC3CCCCC3)c4ccccc14
solubilityDMSO: 10 mg/mL, clear
storage conditiondesiccated
storage temp.2-8°C
Code
Description
Unit Size
List Price
Qty
B4313-5MG
(E/Z)-BCI hydrochloride, >=98% (HPLC)

Unit:5MG
List Price: £205.00
Source:List Price
ADD
Cas Number95130-23-7
This product has met the following criteria: