5-(2-Benzothiazolyl)-3-ethyl-2-[2-(methylphenylamino)ethenyl]-1-phenyl-1H-benzimidazolium iodide, >=98% (HPLC), solid

Code: b2311-5mg D2-231

Not available outside of the UK & Ireland.

Biochem/physiol Actions

5-(2-Benzothiazolyl)-3-et﹤WBR>hyl-2-[2-(methylphenylami﹤WBR>no)-ethenyl]-1-phenyl-1H-﹤WBR>benzimidazolium, or Akt Inhibitor IV, i...


read more

Your Price
£166.00 5MG
REQUEST

Not available outside of the UK & Ireland.

Biochem/physiol Actions

5-(2-Benzothiazolyl)-3-et﹤WBR>hyl-2-[2-(methylphenylami﹤WBR>no)-ethenyl]-1-phenyl-1H-﹤WBR>benzimidazolium, or Akt Inhibitor IV, is a cell-permeable benzimidazole compound that inhibits Akt phosphorylation/activatio﹤WBR>n by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3K. Shown to block Akt-mediated FOXO1a nuclear export (IC﹤SUB>50﹤/SUB> = 0.625μM) and cell proliferation (IC﹤SUB>50﹤/SUB> ﹤ 1.25μM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors, this inhibitor does not affect PI3K.

Features and Benefits

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

5 mg in glass bottle

assay≥98% (HPLC)
coloryellow to orange
formpowder
InChI keyNAYRELMNTQSBIN-UHFFFAOYSA-M
InChI1S/C31H27N4S.HI/c1-3-34-28-22-23(31-32-26-16-10-11-17-29(26)36-31)18-19-27(28)35(25-14-8-5-9-15-25)30(34)20-21-33(2)24-12-6-4-7-13-24;/h4-22H,3H2,1-2H3;1H/q+1;/p-1
Quality Level100
SMILES string[I-].CC[n+]1c(C=CN(C)c2ccccc2)n(-c3ccccc3)c4ccc(cc14)-c5nc6ccccc6s5
solubilityDMSO: 5 mg/mL, clear
storage temp.2-8°C
Cas Number681281-88-9
This product has met the following criteria: