H-89 dihydrochloride hydrate, >=98% (HPLC), powder

Code: b1427-5mg D2-231

Not available outside of the UK & Ireland.

Application

H-89 dihydrochloride hydrate has been used in the inhibition of protein kinase A in Leydig cells, primary calvarial osteoblasts (pOBs), rat granulosa cell line (L...


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£231.00 5MG
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Not available outside of the UK & Ireland.

Application

H-89 dihydrochloride hydrate has been used in the inhibition of protein kinase A in Leydig cells, primary calvarial osteoblasts (pOBs), rat granulosa cell line (LH-15 cells) and human umbilical vein endothelial cells (HUVECs).

Biochem/physiol Actions

H-89 dihydrochloride hydrate is a selective inhibitor of protein kinase A (PKA). It also inhibits potassium (K+) current in rat myocytes. It mediates Na+ transport by interacting with α subunits of epithelial Na+ channel (ENaC).

Selective, potent inhibitor of cAMP-dependent protein kinase.

Features and Benefits

This compound is featured on the PKA & PKG and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

5 mg in glass bottle

assay≥98% (HPLC)
biological sourcesynthetic (organic)
coloroff-white
formpowder
Gene Informationhuman ... PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
InChI keyGKFFJFGBWAGAFD-HZBIHQSRSA-N
InChI1S/C20H20BrN3O2S.2ClH.H2O/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20;;;/h1-10,12,15,22,24H,11,13-14H2;2*1H;1H2/b3-2+;;;
Quality Level100
SMILES stringO.Cl.Cl.Brc1ccc(C=CCNCCNS(=O)(=O)c2cccc3cnccc23)cc1
solubilityDMSO: 10 mg/mL, clear
storage temp.2-8°C
Cas Number130964-39-5
This product has met the following criteria: