Roflumilast

Code: sml1099-10mg D2-231

Not available outside of the UK & Ireland.

Application

Roflumilast has been used to evaluate its effect on acute lung inflammation and chronic lung changes in models of cigarette exposure in mice. It is also used to i...


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Your Price
£68.20 10MG
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Not available outside of the UK & Ireland.

Application

Roflumilast has been used to evaluate its effect on acute lung inflammation and chronic lung changes in models of cigarette exposure in mice. It is also used to investigate its therapeutic potential to ameliorate primary blast-induced deficits in long-term potentiation (LTP).

Biochem/physiol Actions

Roflumilast is a highly potent, orally active, and selective phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 0.8 nM. Roflumilast has anti-inflammatory properties and is used clinically to treat COPD.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

10, 50 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
Gene Informationhuman ... PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)
InChI keyMNDBXUUTURYVHR-UHFFFAOYSA-N
InChI1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
Quality Level100
SMILES stringClC1=CN=CC(Cl)=C1NC(C2=CC=C(OC(F)F)C(OCC3CC3)=C2)=O
solubilityDMSO: 20 mg/mL, clear
storage temp.−20°C
Code
Description
Unit Size
List Price
Qty
SML1099-50MG
Roflumilast >=98% (HPLC)

Unit:50MG
List Price: £268.00
Source:List Price
ADD
Cas Number162401-32-3
This product has met the following criteria: