Not available outside of the UK & Ireland.

Application

MPP+ iodide has been used:to induce oxidative stress in zebrafish embryosfor the inhibition of glutamate uptake in mitochondria of astrocytesin testing cell viability using MTT (3 (4,5-dimethylthiazol)-2-yl-2,5-diphenyltetrazolium bromide) in microglia (BV2) cells

Biochem/physiol Actions

MPP⁺ iodide is an active metabolite of dopaminergic neurotoxin MPTP.

Caution

Photosensitive.

General description

1-Methyl-4-phenylpyridinium (MPP+) induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.

Packaging

1 g in glass bottle

100 mg in glass bottle

Preparation Note

Solutions should be freshly prepared.