Not available outside of the UK & Ireland.

Application

CNQX disodium salt hydrate has been used as: as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110) as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111) as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)

Biochem/physiol Actions

CNQX(6-cyano-7-nitroquinoxaline-2,3-dioneis) is a potent, competitive AMPA/kainate receptor antagonist. It is a quinoxaline derivative and also an antagonist for non-N-methyl-d-aspartate (non-NMDA) glutamate receptor. CNQX mediates depolarization thalamic reticular nucleus via α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs). It displays micromolar affinity towards AMPA/kainate receptor.

Potent, competitive AMPA/kainate receptor antagonist.

Features and Benefits

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Packaging

5, 25, 100 mg in glass bottle