CNQX disodium salt hydrate, >=98% (HPLC), solid

Code: c239-25mg D2-231

Not available outside of the UK & Ireland.

Application

CNQX disodium salt hydrate has been used as: as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(1...


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$720.26 25MG
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Not available outside of the UK & Ireland.

Application

CNQX disodium salt hydrate has been used as: as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110) as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111) as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)

Biochem/physiol Actions

CNQX(6-cyano-7-nitroquinoxaline-2,3-dioneis) is a potent, competitive AMPA/kainate receptor antagonist. It is a quinoxaline derivative and also an antagonist for non-N-methyl-d-aspartate (non-NMDA) glutamate receptor. CNQX mediates depolarization thalamic reticular nucleus via α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs). It displays micromolar affinity towards AMPA/kainate receptor.

Potent, competitive AMPA/kainate receptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

5, 25, 100 mg in glass bottle

assay≥98% (HPLC)
colororange to red
formsolid
Gene Informationhuman ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)
InChI keyLCDWHGXMFAZHEO-UHFFFAOYSA-L
InChI1S/C9H4N4O4.2Na.H2O/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5;;;/h1-2H,(H,11,14)(H,12,15);;;1H2/q;2*+1;/p-2
Quality Level100
SMILES stringO.[Na+].[Na+].[O-]c1nc2cc(C#N)c(cc2nc1[O-])[N+]([O-])=O
solubilityH2O: >2 mg/mL (warmed)
storage conditionprotect from light
Code
Description
Unit Size
List Price
Qty
C239-5MG
CNQX disodium salt hydrate, >=98% (HPLC), solid

Unit:5MG
List Price: $196.43
Source:List Price
ADD
C239-100MG
CNQX disodium salt hydrate, >=98% (HPLC), solid

Unit:100MG
List Price: $1,152.72
Source:List Price
ADD
Cas Number115066-14-3
This product has met the following criteria: