Bryostatin 1, >=99%, solid

Code: b7431-10ug D2-231

Not available outside of the UK & Ireland.

Application

Bryostatin 1 has been used to study its effects on spontaneous Crohn′s disease (CD) like colitis inmice. It has also been used to study its effects as an anthelmi...


read more

Your Price
£240.00 10UG
REQUEST

Not available outside of the UK & Ireland.

Application

Bryostatin 1 has been used to study its effects on spontaneous Crohn′s disease (CD) like colitis inmice. It has also been used to study its effects as an anthelmintic drug on adult Syphacia muris infection in rats.

Biochem/physiol Actions

Macrolactone isolated from the marine bryozoan Bugula neritina that initially activates and subsequently down-regulates protein kinase C (PKC). More potent than phorbol myristate acetate for translocating PKCδ and ε.

Bryostatin 1 (Bry1) is a macrocyclic lactone. This synaptogenic compound is obtained from the marine bryozoanBugula neritina. Bry1 is capable of reversing synaptic loss. It can enable synaptic maturation in animal models with several neurological disorders. It possesses antidepressant activity, when administered intracebroventricularly. Bry1 is known to participate in protecting cell tight junctions (TJs), anti-inflammatory functions and immune regulation.

Other Notes

Binds to glass and plastic in aqueous solutions

Packaging

10 µg in ampule

assay≥99%
colorwhite
formsolid
InChI keyMJQUEDHRCUIRLF-TVIXENOKSA-N
InChI1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1
Quality Level100
SMILES string[H]C(C(=O)OC)=C1/C[C@@]2([H])C[C@]3(O)O[C@]([H])(C[C@@H](O)CC(=O)O[C@H](C[C@]4([H])CC(=C([H])C(=O)OC)[C@H](OC(=O)C=CC=CCCC)[C@@](O)(O4)C(C)(C)C=C[C@@]([H])(C1)O2)[C@@H](C)O)C[C@H](OC(C)=O)C3(C)C
solubilityethanol: soluble, DMSO: soluble
storage temp.−20°C
Cas Number83314-01-6
This product has met the following criteria: