Not available outside of the UK & Ireland.

Application

Bafilomycin A1 has been used:as an autophagy inhibitor to study its effects on hepatic steatosis in human hepatocytesas a vacuolar-type H⁺ -ATPase inhibitor to study its effects on the cell viability, percentage of PI-positive cells, and glucose-stimulated insulin secretion (GSIS) in mice INS-1 cellsas a vacuolar-type H⁺ -ATPase inhibitor to study its effects on tau degradation in human SH-SY5Y cells

Biochem/physiol Actions

A specific inhibitor of vacuolar type H⁺-ATPase (V-ATPase) in animal cells, plant cells and microorganisms.

Bafilomycin A1 inhibits autophagosome-lysosome fusion and autolysosome acidification, the steps involved in the autophagic process that is required for maintaining functional autophagic flux and cellular homeostasis.

General description

Chemical structure: macrolide

Packaging

2, 10 µg in serum bottle