Not available outside of the UK & Ireland.

Application

Antimycin A has been used to study the specific sites of reactive oxygen species production in mitochondria isolated from skeletal muscle of chronic obstructive pulmonary disease patients, and its relationship with local oxidative stress induced by exercise

Antimycin A from Streptomyces sp. has been used:as a respiratory chain inhibitor in neuronal culturesin organello ATP production assay in Trypanosoma brucei cellsin respiration assay for papillary thyroid carcinoma (PTC) cell lines

Biochem/physiol Actions

Inhibitor of electron transfer at complex III. Induces apoptosis.

General description

Chemical structure: peptide

Antimycin is produced by Streptomyces species. It inhibits mitochondrial electron transport chain complex III and favors reactive oxygen species (ROS) production, impairing mitochondrial depolarization. It inhibits nitric oxide-mediated apoptosis and modulatescytochrome C release. It suppresses tumorigenesis in lung cancer cells and could be a potential therapeutic agent.

Packaging

25, 50, 100 mg in glass bottle

Quality

A mixture of antimycins.