Not available outside of the UK & Ireland.

Application

Amantadine hydrochloride has been used: to determine its effectiveness in reducing surgery-induced cognitive impairment to preincubate multipotent stem cells (MSCs), to investigate the cellular internalization pathway to determine whether amantadine-attenuated sepsis-induces neuroinflammation and dysfunction of learning and memory to preincubate primary cultured rat dental pulp stem cells (rDPSCs)to determine the pathway of internalization

Biochem/physiol Actions

Dopamine releaser used to treat Parkinsonism and drug-induced extrapyramidal reactions.

Amantadine hydrochloride is effective against influenza viruses both in vivo and in vitro. It is considered as an antagonist of the N-methyl-D-aspartate (NMDA) type glutamate receptor. Amantadine plays an important role in the release of dopamine, preventing dopamine reuptake and blocking microglial activation and neuroinflammation.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Endo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Amantadine hydrochloride {tricyclo-[3,3,1,1]- deean-l-amine hydrochloride is a drug, which has rimantadine hydrochloride as its analog.

Packaging

5, 25, 100 g in poly bottle