Not available outside of the UK & Ireland.

Application

Anti-AGER (AB2) polyclonal antibody is used to tag advanced glycation end product receptor protein(s) for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques. Anti-AGER (AB2) polyclonal antibody may be used to study the effects/roles of glycation and glyoxidation in cardiovascular disease and diabetes.

Biochem/physiol Actions

AGER mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. It is receptor for amyloid beta peptide.This gene encodes a member of the immunoglobulin superfamily of cell surface molecules. It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products. The gene lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Alternative splicing results in two transcript variants encoding different isoforms.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

The receptor for advanced glycation end products (RAGE or AGER), a member of the immunoglobulin superfamily, is involved in pathologies such as atherosclerosis, micro- and macrovascular diseases, inflammatory diseases and diabetes. RAGE binds advanced glycation end products (AGE) produced by non-enzymatic glycation or glyoxidation of proteins, lipids and nucleic acids.

Immunogen

Synthetic peptide directed towards the C terminal region of human AGER

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Sequence

Synthetic peptide located within the following region: RIRAGNSSPGPGDPGRPGDSRPAHWGHLVAKAATPRRGEEGPRKPGGRGG

Specificity

Anti-RAGE (AB2) polyclonal antibody reacts with human advanced glycosylation end product-specific receptor (AGER).