Not available outside of the UK & Ireland.

Analysis Note

ControlMouse testis tissue lysate

Application

Research Sub CategoryNeuronal & Glial Markers

Research CategoryEpigenetics & Nuclear Function

Anti-LMX-1 Antibody is an antibody against LMX-1 for use in WB.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

LMX-1 is a transcription factor that belongs to the LIM-homeodomain (LIM-HD) transcription factor family. It is induced within the ventral midbrain as a response to early signaling. LMX-1 is a necessary component for the development of the roof plate and for CNS dorsal cell date specification and the development of vertebrae. It is Expressed in roof plate, an organizational locus found in the dorsal CNS that functions to moderate the differentiation and specification of adjacent neurons through the secretion of signaling molecules such as WNT and BMP. Recent studies have indicated that LMX-1 has high potential for stimulating the production of mesencephalic dopamine neurons(mesDA) for the therapeutic treatment Parkinson disease, a condition characterized by dopaminergic neurotransmission decline resulting from the progression of mesDA neuronal degeneration within the substantia nigra pars compacta (SN).

Immunogen

Epitope: C-terminus

GST-tagged recombinant protein corresponding to the C-terminus of hamster LMX-1.

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Physical form

Unpurified rabbit polyclonal serum containing 0.05% sodium azide.

Unpurified

Quality

Evaluated by Western Blot in mouse testis tissue lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected LMX-1 on 10 µg of mouse testis tissue lysate.

Specificity

This antibody recognizes LMX-1.

Storage and Stability

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Target description

~50 kDa observed.