Not available outside of the UK & Ireland.

Application

Anti-G3BP antibody produced in chicken is suitbale for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Ras GTPase-activating protein-binding protein 1 is an enzyme encoded by the G3BP1 gene in humans. It is a ubiquitously expressed cytosolic 68kDa protein that physically associates with the SH3 domain of GAP and is essential for Ras signaling. The protein binds to RasGAP and is overexpressed in many human cancers. Down regulation of G3BP1 suppresses cell growth and induces apoptosis in HCT116 cells. It acts as a potential anti-cancer drug target implicated in several cellular functions.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

Immunogen Sequence: GI # 5031703, sequence 132-350

Recombinant ras-GTPase-activating protein SH3-domain-binding protein

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.