Not available outside of the UK & Ireland.

Biochem/physiol Actions

ED₅₀= ≥5 ng/ml as measured by its ability to enhance IL-6-induced growth inhibition of mouse M1 myeloid leukemic cells

General description

Recombinant, human soluble interleukin-6 receptor expressed in S. frugiperda insect cells. Soluble form of the IL-6 receptor that binds IL-6 and mediates IL-6 signaling through interaction with gp130. Elevated serum levels of soluble IL-6 receptors have been shown to be associated with a number of pathological states including multiple myelomas, adult T cell leukemia, interstitial lung infection, and HIV infection.

Recombinant, human soluble interleukin-6 receptor expressed in S. frugiperda insect cells. Soluble form of the IL-6 receptor that binds IL-6 and mediates IL-6 signaling through interaction with gp 130. Elevated serum levels of soluble IL-6 receptors have been shown to be associated with a number of pathological states, including multiple myelomas, adult T cell leukemia, interstitial lung infection, and HIV infection.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Schobitz, B., et al. 1995. FASEB J. 9, 659.Yokoyama, A., et al. 1995. Clin. Exp. Immunol. 100, 325.Suzuki, H., et al. 1993. Eur. J. Immunol. 23, 1078.Lust, J.A., et al. 1992. Cytokine 4, 96.Sugita, T., et al. 1990. J. Exp. Med. 171, 2001.Yamasaki, K., et al. 1988. Science241, 825.

Packaging

25 µg in Plastic ampoule

Physical form

Lyophilized from sterile-filtered PBS, 50 µg BSA/µg IL-6 receptor.

Reconstitution

Reconstitute to a concentration ≥100 µg/ml with sterile PBS containing at least 0.1% HSA or BSA.

Warning

Toxicity: Standard Handling (A)