4-Hydroxytamoxifen, (E) and (Z) isomers (50:50), analytical standard

Code: 94873-10mg D2-231

Not available outside of the UK & Ireland.

Application

4-Hydroxytamoxifen may be used as a reference standard in the determination of 4-hydroxythmoxifen in plasma samples using high-performance liquid chromatography w...


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$175.17 10MG
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Not available outside of the UK & Ireland.

Application

4-Hydroxytamoxifen may be used as a reference standard in the determination of 4-hydroxythmoxifen in plasma samples using high-performance liquid chromatography with fluorescence detection (HPLC).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Metabolite of the chemotherapeutic drug tamoxifen, exhibiting more potent estrogen agonist/antagonist activity than the parent drug. Also active as intra-membranous inhibitor of lipid peroxidation.

General description

4-Hydroxytamoxifen is a first generation, selective estrogen receptor modulator (SERM) that functions as an antagonist in breast cancer cells but can display estrogen-like activities in the uterus and bone.

application(s)forensics and toxicologypharmaceutical (small molecule)
assay≥97.5% (HPLC)
formatneat
gradeanalytical standard
impurities≤5.0% water
InChI keyZJLDABGSDWXVGE-BDSXMVAQSA-N
InChI1S/2C26H29NO2/c2*1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h2*5-17,28H,4,18-19H2,1-3H3/b26-25+;26-25-
Quality Level100
shelf lifelimited shelf life, expiry date on the label
SMILES stringCCC(c1ccccc1)=C(/c2ccc(O)cc2)c3ccc(OCCN(C)C)cc3.CCC(c4ccccc4)=C(c5ccc(O)cc5)c6ccc(OCCN(C)C)cc6
technique(s)gas chromatography (GC): suitable, HPLC: suitable
Cas Number68392-35-8
This product has met the following criteria: