Not available outside of the UK & Ireland.

Application

Sodium orthovandate was used to prepare the stop solution in dephosphorylation assay of insulin receptor kinase.²⁶ It was one of the reagents used in the development of Matrix ChIP that utilizes surface-immobilized antibodies.²⁷

Biochem/physiol Actions

Sodium orthovandate suppresses the activation of p53-mediated apoptosis triggered in response to radiation. It reduces the detrimental effects of hematopoietic syndrome, hematopoiesis and delayed genotoxic effects of induced by total body irradiation of mice.²⁴ In combination with menadione, orthovandate prevents the migration of detached human glioma cells in response to anti-cancer drugs.²⁵

Inhibits ATPase, alkaline phosphatase and tyrosine phosphatase. Decavanadate, which is formed at acidic pH, inhibits inositol 1,4,5-trisphosphate (IP₃)-induced Ca²⁺ release from endocrine cells and blocks IP₃ binding to its receptor in brain tissue.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

10, 50, 250 g in poly bottle