Not available outside of the UK & Ireland.
Application
α-Methyl-L-tyrosine has been used as an inhibitor tyrosine hydroxylase: to test its effect during acute stress in zebrafish in cannabinoid receptor type-1 (CB1) knockout and wild type mice, to test its effect on norepinephrine turnover to test catecholaminesdepletion on stress in rat spleen samplesto block dopamine synthesis in dopaminergic neurons
α-Methyl-L-tyrosine is used to determine whether Fe2/ methamphetamine (METH) -induced cell death is dependent on cytosolic dopamine and iron mediated oxidative stress.
Biochem/physiol Actions
α-Methyl-L-tyrosine (L-AMPT) acts as a competitive inhibitor of tyrosine hydroxylase and inhibits the conversion of tyrosine to L-DOPA and eventually lowers dopamine synthesis in cytosol. AMPT at low concentrations can be used as a potent therapeutic for refractory dystonia or dyskinesia. It also helps in decreasing catecholamine concentration in pheochromocytoma patients.
Tyrosine hydroxylase inhibitor.
Other Notes
Active isomer
Packaging
1, 5 g in poly bottle
100, 250 mg in poly bottle
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