Not available outside of the UK & Ireland.

Application

Tomatidine hydrochloride has been used:to evaluate its effect on nasopharyngeal carcinoma using cell proliferation and flow cytometry assayas a negative control in the non-specific inhibition on hedgehog signaling in hepatocellular carcinoma cell linesas a control for cell growth assay and expression studies in pancreatic cancer cells

Biochem/physiol Actions

Potent inhibitor of Staphylococcus aureus small-colony variants typically seen as complications of cystic fibrosis, with little or no effect on normal S. aureus strains. Also shows antiinflammatory activity by indirectly inhibiting iNOS and COX-2 pathways.

Tomatidine induces the anti-oxidant nuclear factor E2-related factor 2 (Nrf2) and mitophagy, favoring the delay in aging process in C.elegans. It is an inhibitor of muscle atrophy and promotes anabolism in muscle by activating mammalian target of rapamycin complex 1 (mTORC1). It may be useful for treating skeletal muscle atrophy.

General description

Tomatidine is a glycoalkaloid and an aglycone metabolite of tomatine present in high levels in unripe tomato.

Packaging

25, 100 mg in poly bottle